Yes, you read that right. There’s one skincare brand I’m genuinely nervous about quitting — because the results have been that good.

I’m talking about OneSkin and, more specifically, their OS-01 peptide.

Now, there are plenty of products I’ve tested over the years that earn a spot in my routine. But very rarely do I find something that feels essential. OneSkin has become one of those brands.

And here’s the funny part — I didn’t even start with the face cream. I started with their Body Supplement. Honestly? I wasn’t expecting much. But three months later, the crepey, wrinkly skin on my arms had practically disappeared. Gone.

That’s when I had to stop and ask: What on earth is in this that’s making such a difference?

What Is the OS-01 Peptide?

I’m not a scientist, dermatologist or skincare professional — I’m just a skincare-obsessed woman trying to find products that help my skin stay healthier for longer.

Here’s what I’ve learned:

Peptides are short chains of amino acids that act like little messengers, telling your skin to do certain jobs — like make more collagen, calm inflammation or repair damaged areas.

The OS-01 peptide is different because it targets one of the root causes of skin aging: something called cellular senescence (also nicknamed “zombie cells”).

As we age, some skin cells basically retire. They stop dividing, hang around, and send out inflammatory signals that make surrounding cells age faster too. Think of one moldy raspberry ruining the whole basket.

OS-01 helps switch off those damaged cells, so your skin behaves more like it did when it was younger. That means better collagen production, improved thickness and faster healing.

How It Stands Apart From Other Peptides

There are lots of well-known peptides out there — Matrixyl for collagen, copper peptides for healing, Argireline (aka “Botox in a bottle”) for expression lines.

But none of those deal directly with senescent, zombie-like cells. OS-01 does. That’s its unique edge.

What the Research Says

OneSkin has actually done studies — and as you know, I love when brands share their science.

A lab study with the Face Supplement showed a 15% improvement in skin barrier, plus reduced wrinkles and smoother texture.
A clinical split-face trial (half face treated with OS-01, half with placebo) showed better hydration, stronger barrier function and healthier-looking skin on the OS-01 side.
Even compared to retinol, OS-01 stood out. Retinol compromised skin’s cellular structure, while OS-01 increased epidermal thickness by 23%.

That’s impressive.

My Personal Experience

Like I said, I started with the Body Supplement — and it completely transformed the crepey skin on my arms. No more wrinkles. None.

Then I moved on to the Eye Supplement, which has the highest concentration of OS-01. Because the skin around our eyes is thinner and ages faster, this product was designed to thicken, hydrate and plump that delicate area.

The very first time I tried it, I bought another one immediately. It’s been a daily staple ever since.

Finally, I added the Face Supplement. It focuses on barrier strength, radiance, and firmness. For me, it’s not hydrating enough to use as my only moisturizer — but for many people, it could be. I layer another cream on top and that works perfectly.

OneSkin’s formulas also include niacinamide (brightening + barrier support), hyaluronic acid and squalane (hydration + plumping) and ceramides (to lock it all in). Plus, they’re fragrance-free and cruelty-free.

Who’s Behind OneSkin?

This isn’t just another beauty brand story. OneSkin was founded in 2016 by four Brazilian women scientists — all with PhDs in areas like stem cell research and bioinformatics.

Their mission? To answer a simple but important question: Do anti-aging products actually work?

Most didn’t. So they set out to create something that did. After testing more than 900 peptides, they landed on OS-01 — a breakthrough designed to keep skin healthier, not just prettier.

Think of it less like beauty cream and more like preventive medicine for your skin.

Final Thoughts

Here’s the truth: I didn’t expect to love OneSkin this much. But now, after over a year of using their products, my skin is in the best place it’s ever been.

The OS-01 peptide doesn’t just mask aging — it targets the why behind it. And that’s why I keep going back.

It’s not cheap, but if you’re serious about longevity skincare, it’s one of the few brands really putting their research where their claims are.

And yes, I use my own discount code when I restock.

Have you tried OneSkin or any other peptide products? Let me know in the comments — I love hearing what’s worked (or not worked!) for you.

Until next time, here’s to skin that’s not just looking better, but staying healthier.

The Skincare Brand I’m Afraid to Stop Using